Iron-Catalyzed Cross-Coupling Reactions Tuned by Bulky<i>Ortho</i>-Phenylene Bisphosphine Ligands

The significant progress made in the context of iron-catalyzed cross-coupling reactions past several years has boosted competition with well-known nickel and palladium catalyst systems. Iron-catalyzed protocols not only benefit from economic toxicology standpoints, but also exhibit a range reactivities tolerate many functional groups. To date iron systems have been developed, ranging use simple salts to more complex stoichiometric/catalytic modifiers. Effective N-heterocyclic carbenes bisphosphine ligands developed for organic electrophiles using diverse organometallic reagents. Indeed, field is important new applications modern synthetic chemistry. This account summarizes recent developments practical novel employing bulky o-phenylene their mechanistic views.